Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal m...
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
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Author / Creator
Kwapis, Janine L. , Alaghband, Yasaman , Kramár, Enikö A. , López, Alberto J. , Vogel Ciernia, Annie , White, André O. , Shu, Guanhua , Rhee, Diane , Michael, Christina M. , Montellier, Emilie , Liu, Yu , Magnan, Christophe N. , Chen, Siwei , Sassone-Corsi, Paolo , Baldi, Pierre , Matheos, Dina P. and Wood, Marcelo A.
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term...
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Full title
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory
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TN_cdi_doaj_primary_oai_doaj_org_article_8214879eac4444f79329a0009fdad2ee
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8214879eac4444f79329a0009fdad2ee
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05868-0
