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Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal m...

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal m...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8214879eac4444f79329a0009fdad2ee

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

About this item

Full title

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-08, Vol.9 (1), p.3323-14, Article 3323

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term...

Alternative Titles

Full title

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8214879eac4444f79329a0009fdad2ee

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8214879eac4444f79329a0009fdad2ee

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-05868-0

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