Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell ly...
Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma. A major mutagenic process in DLBCL is aberrant somatic hypermutation (aSHM) by activation-induced cytidine deaminase (AID), which occurs preferentially at RCH/TW sequence motifs proximal to transcription start sites. Splice sequences are highly conserved, rich in RCH/TW motifs, and...
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Full title
Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma
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TN_cdi_doaj_primary_oai_doaj_org_article_824737d499234092909086ca6fbf0fc0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_824737d499234092909086ca6fbf0fc0
Other Identifiers
ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-024-01960-w
