Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in...
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice
About this item
Full title
Author / Creator
dos Santos, Cristiane , Cambraia, Amanda , Shrestha, Shristi , Cutler, Melanie , Cottam, Matthew , Perkins, Guy , Lev-Ram, Varda , Roy, Birbickram , Acree, Christopher , Kim, Keun-Young , Deerinck, Thomas , Dean, Danielle , Cartailler, Jean Philippe , MacDonald, Patrick E. , Hetzer, Martin , Ellisman, Mark and Arrojo e Drigo, Rafael
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Caloric restriction (CR) can extend the organism life- and health-span by improving glucose homeostasis. How CR affects the structure-function of pancreatic beta cells remains unknown. We used single nucleus transcriptomics to show that CR increases the expression of genes for beta cell identity, protein processing, and organelle homeostasis. Gene...
Alternative Titles
Full title
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice
Authors, Artists and Contributors
Author / Creator
Cambraia, Amanda
Shrestha, Shristi
Cutler, Melanie
Cottam, Matthew
Perkins, Guy
Lev-Ram, Varda
Roy, Birbickram
Acree, Christopher
Kim, Keun-Young
Deerinck, Thomas
Dean, Danielle
Cartailler, Jean Philippe
MacDonald, Patrick E.
Hetzer, Martin
Ellisman, Mark
Arrojo e Drigo, Rafael
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_825bdbca87c34b91be5bcf6352a2195f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_825bdbca87c34b91be5bcf6352a2195f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-53127-2
