Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection
Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Reproducibility of hits from independent CRISPR or siRNA screens is poor. This is partly due to data normalization primarily addressing technical variability within independent screens, and not the technical differences between them.
We present "rscreenorm", a method that standardizes the functional data ranges between screens using assay contro...
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Full title
Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection
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TN_cdi_doaj_primary_oai_doaj_org_article_826f3204ee2b48118fd68b46cacf334f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_826f3204ee2b48118fd68b46cacf334f
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ISSN
1471-2105
E-ISSN
1471-2105
DOI
10.1186/s12859-018-2306-z
