Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice
Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice
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Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer's disease (AD). Tau derived from AD patients' brains induces tau aggregation in a prion-like manner when injected into susceptible mouse models.Here we investigated whether cerebrospinal fluid (CSF) collected from patients diagnosed with probable AD or mild cognitive impair...
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Full title
Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice
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TN_cdi_doaj_primary_oai_doaj_org_article_82fce56f28d34a8fb864ea0b8277378e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_82fce56f28d34a8fb864ea0b8277378e
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-019-0725-3
