Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion m...
Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The functional effect of a gene edit by designer nucleases depends on the DNA repair outcome at the targeted locus. While non-homologous end joining (NHEJ) repair results in various mutations, microhomology-mediated end joining (MMEJ) creates precise deletions based on the alignment of flanking microhomologies (µHs). Recently, the sequence context...
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Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
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TN_cdi_doaj_primary_oai_doaj_org_article_83dd1a923e3149b5847e613384f3d67a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_83dd1a923e3149b5847e613384f3d67a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12829-8
