Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutami...
Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity
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Author / Creator
Westbrook, Thomas C. , Guan, Xiangnan , Rodansky, Eva , Flores, Diana , Liu, Chia Jen , Udager, Aaron M. , Patel, Radhika A. , Haffner, Michael C. , Hu, Ya-Mei , Sun, Duanchen , Beer, Tomasz M. , Foye, Adam , Aggarwal, Rahul , Quigley, David A. , Youngren, Jack F. , Ryan, Charles J. , Gleave, Martin , Wang, Yuzhuo , Huang, Jiaoti , Coleman, Ilsa , Morrissey, Colm , Nelson, Peter S. , Evans, Christopher P. , Lara, Primo , Reiter, Robert E. , Witte, Owen , Rettig, Matthew , Wong, Christopher K. , Weinstein, Alana S. , Uzunangelov, Vlado , Stuart, Josh M. , Thomas, George V. , Feng, Felix Y. , Small, Eric J. , Yates, Joel A. , Xia, Zheng and Alumkal, Joshi J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The androgen receptor (AR) signaling inhibitor enzalutamide (enza) is one of the principal treatments for metastatic castration-resistant prostate cancer (CRPC). Several emergent enza clinical resistance mechanisms have been described, including lineage plasticity in which the tumors manifest reduced dependency on the AR. To improve our understandi...
Alternative Titles
Full title
Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity
Authors, Artists and Contributors
Author / Creator
Guan, Xiangnan
Rodansky, Eva
Flores, Diana
Liu, Chia Jen
Udager, Aaron M.
Patel, Radhika A.
Haffner, Michael C.
Hu, Ya-Mei
Sun, Duanchen
Beer, Tomasz M.
Foye, Adam
Aggarwal, Rahul
Quigley, David A.
Youngren, Jack F.
Ryan, Charles J.
Gleave, Martin
Wang, Yuzhuo
Huang, Jiaoti
Coleman, Ilsa
Morrissey, Colm
Nelson, Peter S.
Evans, Christopher P.
Lara, Primo
Reiter, Robert E.
Witte, Owen
Rettig, Matthew
Wong, Christopher K.
Weinstein, Alana S.
Uzunangelov, Vlado
Stuart, Josh M.
Thomas, George V.
Feng, Felix Y.
Small, Eric J.
Yates, Joel A.
Xia, Zheng
Alumkal, Joshi J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_84a852fcb0624999ab330bdca23f4d3f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_84a852fcb0624999ab330bdca23f4d3f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32701-6
