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LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
Author / Creator:Sehrawat, Archana ; Gao, Lina ; Wang, Yuliang ; Bankhead, Armand ; McWeeney, Shannon K. ; King, Carly J. ; Schwartzman, Jacob ; Urrutia, Joshua ; Bisson, William H. ; Coleman, Daniel J. ; Joshi, Sunil K. ; Kim, Dae-Hwan ; Sampson, David A. ; Weinmann, Sheila ; Kallakury, Bhaskar V. S. ; Berry, Deborah L. ; Haque, Reina ; Van Den Eeden, Stephen K. ; Sharma, Sunil ; Bearss, Jared ; Beer, Tomasz M. ; Thomas, George V. ; Heiser, Laura M. ; Alumkal, Joshi J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.E4179-E4188
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Intermediate clinical endpoints for surrogacy in localised prostate cancer: an aggregate meta-analysis
Author / Creator:Gharzai, Laila A, MD ; Jiang, Ralph, BS ; Wallington, David, MD ; Jones, Gavin, MD ; Birer, Samuel, MD ; Jairath, Neil, BS ; Jaworski, Elizabeth M, MD ; McFarlane, Matthew R, MD ; Mahal, Brandon A, MD ; Nguyen, Paul L, Prof ; Sandler, Howard, Prof ; Morgan, Todd M, MD ; Reichert, Zachery R, MD ; Alumkal, Joshi J, MD ; Mehra, Rohit, MD ; Kishan, Amar U, MD ; Fizazi, Karim, Prof ; Halabi, Susan, Prof ; Schaeffer, Edward M, Prof ; Feng, Felix Y, Prof ; Elliott, David, MD ; Dess, Robert T, MD ; Jackson, William C, MD ; Schipper, Matthew J, PhD ; Spratt, Daniel E, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2021-03, Vol.22 (3), p.402-410
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A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone
Author / Creator:Graff, Julie N ; Beer, Tomasz M ; Alumkal, Joshi J ; Slottke, Rachel E ; Redmond, William L ; Thomas, George V ; Thompson, Reid F ; Wood, Mary A ; Koguchi, Yoshinobu ; Chen, Yiyi ; Latour, Emile ; Bergan, Raymond C ; Drake, Charles G ; Moran, Amy E
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2020-07, Vol.8 (2), p.e000642
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Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity
Author / Creator:Westbrook, Thomas C. ; Guan, Xiangnan ; Rodansky, Eva ; Flores, Diana ; Liu, Chia Jen ; Udager, Aaron M. ; Patel, Radhika A. ; Haffner, Michael C. ; Hu, Ya-Mei ; Sun, Duanchen ; Beer, Tomasz M. ; Foye, Adam ; Aggarwal, Rahul ; Quigley, David A. ; Youngren, Jack F. ; Ryan, Charles J. ; Gleave, Martin ; Wang, Yuzhuo ; Huang, Jiaoti ; Coleman, Ilsa ; Morrissey, Colm ; Nelson, Peter S. ; Evans, Christopher P. ; Lara, Primo ; Reiter, Robert E. ; Witte, Owen ; Rettig, Matthew ; Wong, Christopher K. ; Weinstein, Alana S. ; Uzunangelov, Vlado ; Stuart, Josh M. ; Thomas, George V. ; Feng, Felix Y. ; Small, Eric J. ; Yates, Joel A. ; Xia, Zheng ; Alumkal, Joshi J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-09, Vol.13 (1), p.5345-5345, Article 5345
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BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer
Author / Creator:Coleman, Daniel J. ; Gao, Lina ; King, Carly J. ; Schwartzman, Jacob ; Urrutia, Joshua ; Sehrawat, Archana ; Tayou, Junior ; Balter, Ariel ; Burchard, Julja ; Chiotti, Kami E. ; Derrick, Daniel S. ; Sun, Duanchen ; Xia, Zheng ; Heiser, Laura M. ; Alumkal, Joshi J.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2019-07, Vol.38 (28), p.5658-5669
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Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer
Author / Creator:Coleman, Daniel J. ; Gao, Lina ; Schwartzman, Jacob ; Korkola, James E. ; Sampson, David ; Derrick, Daniel S. ; Urrutia, Joshua ; Balter, Ariel ; Burchard, Julja ; King, Carly J. ; Chiotti, Kami E. ; Heiser, Laura M. ; Alumkal, Joshi J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-03, Vol.9 (1), p.3823-3823, Article 3823
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Implementing a comprehensive translational oncology platform: from molecular testing to actionability
Author / Creator:Mitri, Zahi I ; Parmar, Swapnil ; Johnson, Brett ; Kolodzie, Annette ; Keck, Jamie M ; Morris, Max ; Guimaraes, Alexander R ; Beckett, Brooke R ; Borate, Uma ; Lopez, Charles D ; Kemmer, Kathleen A ; Alumkal, Joshi J ; Beer, Tomasz M ; Corless, Christopher L ; Mills, Gordon B ; Gray, Joe W ; Bergan, Raymond C
Publisher:England: BioMed Central Ltd
Journal title:Journal of translational medicine, 2018-12, Vol.16 (1), p.358-358, Article 358
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Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma
Author / Creator:Gao, Bei ; Lue, Hui-Wen ; Podolak, Jennifer ; Fan, Sili ; Zhang, Ying ; Serawat, Archana ; Alumkal, Joshi J ; Fiehn, Oliver ; Thomas, George V
Publisher:Switzerland: MDPI AG
Journal title:Metabolites, 2019-04, Vol.9 (5), p.82
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Survival by first‐line therapy and prognostic group among men with metastatic castration‐resistant prostate cancer
Author / Creator:Caram, Megan E. V. ; Kumbier, Kyle ; Tsao, Phoebe A. ; Burns, Jennifer ; Sparks, Jordan B. ; Stensland, Kristian D. ; Reichert, Zachery R. ; Alumkal, Joshi J. ; Hollenbeck, Brent K. ; Shahinian, Vahakn ; Tsodikov, Alexander ; Skolarus, Ted A.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2024-06, Vol.13 (12), p.e7334-n/a
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Randomized, Open-Label Phase 2 Study of Apalutamide plus Androgen Deprivation Therapy versus Apalutamide Monotherapy versus Androgen Deprivation Monotherapy in Patients with Biochemically Recurrent Pr...
Author / Creator:Aggarwal, Rahul ; Alumkal, Joshi J. ; Szmulewitz, Russell Z. ; Higano, Celestia S. ; Bryce, Alan H. ; Lopez-Gitlitz, Angela ; McCarthy, Sharon A. ; Miladinovic, Branko ; McQuarrie, Kelly ; Thomas, Shibu ; Zhang, Ke ; Small, Eric J.
Publisher:Egypt: Hindawi
Journal title:Prostate cancer, 2022-09, Vol.2022, p.5454727-12
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Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data
Author / Creator:Sun, Duanchen ; Guan, Xiangnan ; Moran, Amy E. ; Wu, Ling-Yun ; Qian, David Z. ; Schedin, Pepper ; Dai, Mu-Shui ; Danilov, Alexey V. ; Alumkal, Joshi J. ; Adey, Andrew C. ; Spellman, Paul T. ; Xia, Zheng
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2022-04, Vol.40 (4), p.527-538
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The DNA methylation landscape of advanced prostate cancer
Author / Creator:Zhao, Shuang G. ; Chen, William S. ; Li, Haolong ; Foye, Adam ; Zhang, Meng ; Sjöström, Martin ; Aggarwal, Rahul ; Playdle, Denise ; Liao, Arnold ; Alumkal, Joshi J. ; Das, Rajdeep ; Chou, Jonathan ; Hua, Junjie T. ; Barnard, Travis J. ; Bailey, Adina M. ; Chow, Eric D. ; Perry, Marc D. ; Dang, Ha X. ; Yang, Rendong ; Moussavi-Baygi, Ruhollah ; Zhang, Li ; Alshalalfa, Mohammed ; Laura Chang, S. ; Houlahan, Kathleen E. ; Shiah, Yu-Jia ; Beer, Tomasz M. ; Thomas, George ; Chi, Kim N. ; Gleave, Martin ; Zoubeidi, Amina ; Reiter, Robert E. ; Rettig, Matthew B. ; Witte, Owen ; Yvonne Kim, M. ; Fong, Lawrence ; Spratt, Daniel E. ; Morgan, Todd M. ; Bose, Rohit ; Huang, Franklin W. ; Li, Hui ; Chesner, Lisa ; Shenoy, Tanushree ; Goodarzi, Hani ; Asangani, Irfan A. ; Sandhu, Shahneen ; Lang, Joshua M. ; Mahajan, Nupam P. ; Lara, Primo N. ; Evans, Christopher P. ; Febbo, Phillip ; Batzoglou, Serafim ; Knudsen, Karen E. ; He, Housheng H. ; Huang, Jiaoti ; Zwart, Wilbert ; Costello, Joseph F. ; Luo, Jianhua ; Tomlins, Scott A. ; Wyatt, Alexander W. ; Dehm, Scott M. ; Ashworth, Alan ; Gilbert, Luke A. ; Boutros, Paul C. ; Farh, Kyle ; Chinnaiyan, Arul M. ; Maher, Christopher A. ; Small, Eric J. ; Quigley, David A. ; Feng, Felix Y.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2020-08, Vol.52 (8), p.778-789
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Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance
Author / Creator:Alumkal, Joshi J. ; Sun, Duanchen ; Lu, Eric ; Beer, Tomasz M. ; Thomas, George V. ; Latour, Emile ; Aggarwal, Rahul ; Cetnar, Jeremy ; Ryan, Charles J. ; Tabatabaei, Shaadi ; Bailey, Shawna ; Turina, Claire B. ; Quigley, David A. ; Guan, Xiangnan ; Foye, Adam ; Youngren, Jack F. ; Urrutia, Joshua ; Huang, Jiaoti ; Weinstein, Alana S. ; Friedl, Verena ; Rettig, Matthew ; Reiter, Robert E. ; Spratt, Daniel E. ; Gleave, Martin ; Evans, Christopher P. ; Stuart, Joshua M. ; Chen, Yiyi ; Feng, Felix Y. ; Small, Eric J. ; Witte, Owen N. ; Xia, Zheng
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-06, Vol.117 (22), p.12315-12323
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A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer
Author / Creator:Alumkal, Joshi J. ; Slottke, Rachel ; Schwartzman, Jacob ; Cherala, Ganesh ; Munar, Myrna ; Graff, Julie N. ; Beer, Tomasz M. ; Ryan, Christopher W. ; Koop, Dennis R. ; Gibbs, Angela ; Gao, Lina ; Flamiatos, Jason F. ; Tucker, Erin ; Kleinschmidt, Richard ; Mori, Motomi
Publisher:Boston: Springer US
Journal title:Investigational new drugs, 2015-04, Vol.33 (2), p.480-489
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MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
Author / Creator:Nickols, Nicholas G. ; Nazarian, Ramin ; Zhao, Shuang G. ; Tan, Victor ; Uzunangelov, Vladislav ; Xia, Zheng ; Baertsch, Robert ; Neeman, Elad ; Gao, Allen C. ; Thomas, George V. ; Howard, Lauren ; De Hoedt, Amanda M. ; Stuart, Josh ; Goldstein, Theodore ; Chi, Kim ; Gleave, Martin E. ; Graff, Julie N. ; Beer, Tomasz M. ; Drake, Justin M. ; Evans, Christopher P. ; Aggarwal, Rahul ; Foye, Adam ; Feng, Felix Y. ; Small, Eric J. ; Aronson, William J. ; Freedland, Stephen J. ; Witte, Owen N. ; Huang, Jiaoti ; Alumkal, Joshi J. ; Reiter, Robert E. ; Rettig, Matthew B.
Publisher:London: Nature Publishing Group UK
Journal title:Prostate cancer and prostatic diseases, 2019-12, Vol.22 (4), p.531-538
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Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer
Author / Creator:Hussain, Maha ; Carducci, Michael A. ; Slovin, Susan ; Cetnar, Jeremy ; Qian, Jiang ; McKeegan, Evelyn M. ; Refici-Buhr, Marion ; Chyla, Brenda ; Shepherd, Stacie P. ; Giranda, Vincent L. ; Alumkal, Joshi J.
Publisher:New York: Springer US
Journal title:Investigational new drugs, 2014-10, Vol.32 (5), p.904-912
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Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL
Author / Creator:Chow, Marilynn ; Gao, Lina ; MacManiman, Jason D. ; Bicocca, Vincent T. ; Chang, Bill H. ; Alumkal, Joshi J. ; Tyner, Jeffrey W.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2018-09, Vol.37 (38), p.5221-5232
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Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Author / Creator:Reichert, Zachery R ; Kasputis, Tadas ; Nallandhighal, Srinivas ; Abusamra, Sophia M ; Kasputis, Amy ; Haruray, Saloni ; Wang, Yugang ; Williams, Shamara ; Singhal, Udit ; Alva, Ajjai ; Cackowski, Frank C ; Caram, Megan E V ; Palmbos, Phillip L ; Yentz, Sarah E ; Smith, David C ; Alumkal, Joshi J ; Morgan, Todd M
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-12, Vol.23 (1), p.4
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De novo neuroendocrine transdifferentiation in primary prostate cancer–a phenotype associated with advanced clinico-pathologic features and aggressive outcome
Author / Creator:Abdulfatah, Eman ; Reichert, Zachery R. ; Davenport, Matthew S. ; Chinnaiyan, Arul M. ; Dadhania, Vipulkumar ; Wang, Xiaoming ; Mannan, Rahul ; Kunju, Lakshmi P. ; Hollenbeck, Brent K. ; Montgomery, Jeffrey S. ; Kaffenberger, Samuel D. ; Morgan, Todd M. ; Alva, Ajjai S. ; Palapattu, Ganesh S. ; Vaishampayan, Ulka N. ; Alumkal, Joshi J. ; Spratt, Daniel E. ; Udager, Aaron M. ; Mehra, Rohit
Publisher:New York: Springer US
Journal title:Medical oncology (Northwood, London, England), 2021-03, Vol.38 (3), p.26-26, Article 26
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Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer
Author / Creator:Chen, William S. ; Feng, Eric L. ; Aggarwal, Rahul ; Foye, Adam ; Beer, Tomasz M. ; Alumkal, Joshi J. ; Gleave, Martin ; Chi, Kim N. ; Reiter, Robert E. ; Rettig, Matthew B. ; Evans, Christopher P. ; Small, Eric J. ; Sharifi, Nima ; Zhao, Shuang G.
Publisher:London: Nature Publishing Group UK
Journal title:Prostate cancer and prostatic diseases, 2020-06, Vol.23 (2), p.316-323
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LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

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Intermediate clinical endpoints for surrogacy in localised prostate cancer: an aggregate meta-analysis

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A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone

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Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity

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BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

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Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

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Implementing a comprehensive translational oncology platform: from molecular testing to actionability

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Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma

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Survival by first‐line therapy and prognostic group among men with metastatic castration‐resistant prostate cancer

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Randomized, Open-Label Phase 2 Study of Apalutamide plus Androgen Deprivation Therapy versus Apalutamide Monotherapy versus Androgen Deprivation Monotherapy in Patients with Biochemically Recurrent Pr...

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Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data

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The DNA methylation landscape of advanced prostate cancer

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Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance

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A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

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MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer

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Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

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Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

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Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

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De novo neuroendocrine transdifferentiation in primary prostate cancer–a phenotype associated with advanced clinico-pathologic features and aggressive outcome

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Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer

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