IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-...
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
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Author / Creator
Lin, Hong , Yan, Yuan , Luo, Yifan , So, Wing Yan , Wei, Xiayun , Zhang, Xiaozhe , Yang, Xiaoli , Zhang, Jun , Su, Yang , Yang, Xiuyan , Zhang, Bobo , Zhang, Kangjun , Jiang, Nan , Chow, Billy Kwok Chong , Han, Weiping , Wang, Fengchao and Rao, Feng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
COP1 and COP9 signalosome (CSN) are the substrate receptor and deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear. Here, we uncover COP1–CSN antagonism during glucose-induced insulin secretion. Heterozygous
Csn2
WT/K70E
mice with partially disrupted binding of IP
6
, a CSN cofactor, display co...
Alternative Titles
Full title
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_85171494d8b0463f93a5c8fdead68f04
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_85171494d8b0463f93a5c8fdead68f04
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22941-3
