DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial methylation domains. Here we find that immunomodulatory pathway genes are concentrated in these doma...
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Full title
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
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TN_cdi_doaj_primary_oai_doaj_org_article_85658e71ba8442669c3d3515dd6416cb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_85658e71ba8442669c3d3515dd6416cb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12159-9
