Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer
Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in the colon is not clear. Here, we show that P1-HNF4α is expressed primarily in the differentiated compartment of the mouse colonic crypt and P2-HNF4α in the proliferative compar...
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Full title
Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_8567af03de6140959642cdc4b36f09cb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8567af03de6140959642cdc4b36f09cb
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.10903
