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Profilin 1 deficiency drives mitotic defects and reduces genome stability

Profilin 1 deficiency drives mitotic defects and reduces genome stability

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8609517adcae44f0a77a5dd393eabeec

Profilin 1 deficiency drives mitotic defects and reduces genome stability

About this item

Full title

Profilin 1 deficiency drives mitotic defects and reduces genome stability

Publisher

London: Nature Publishing Group UK

Journal title

Communications biology, 2023-01, Vol.6 (1), p.9-9, Article 9

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Profilin 1—encoded by
PFN1—
is a small actin-binding protein with a tumour suppressive role in various adenocarcinomas and pagetic osteosarcomas. However, its contribution to tumour development is not fully understood. Using fix and live cell imaging, we report that Profilin 1 inactivation results in multiple mitotic defects, manifested promi...

Alternative Titles

Full title

Profilin 1 deficiency drives mitotic defects and reduces genome stability

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8609517adcae44f0a77a5dd393eabeec

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8609517adcae44f0a77a5dd393eabeec

Other Identifiers

ISSN

2399-3642

E-ISSN

2399-3642

DOI

10.1038/s42003-022-04392-8

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