APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient micr...
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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The major genetic risk factor for Alzheimer’s disease (AD),
APOE4
, accelerates beta-amyloid (Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or astrocytes is debated. We express here the human APOE isoforms in astrocytes in an
Apoe
-deficient AD mouse model. This is not only sufficient to restore the amy...
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APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
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TN_cdi_doaj_primary_oai_doaj_org_article_8623492f8242414195b2b4f5b3e4002e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8623492f8242414195b2b4f5b3e4002e
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ISSN
1757-4684,1757-4676
E-ISSN
1757-4684
DOI
10.1038/s44321-024-00162-7
