Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Infection by viruses, including herpes simplex virus-1 (HSV-1), and cellular stresses cause widespread disruption of transcription termination (DoTT) of RNA polymerase II (RNAPII) in host genes. However, the underlying mechanisms remain unclear. Here, we demonstrate that the HSV-1 immediate early protein ICP27 induces DoTT by directly binding to th...
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Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
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TN_cdi_doaj_primary_oai_doaj_org_article_86795a19df404ef6a9b5cb941f4f5451
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_86795a19df404ef6a9b5cb941f4f5451
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14109-x
