The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
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Switzerland: Frontiers Research Foundation
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Language
English
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Publisher
Switzerland: Frontiers Research Foundation
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Contents
Possession of the ε4 allele of apolipoprotein E (
) is the major genetic risk factor for late-onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the precise cause of this increased AD risk is not yet known. In order to gain a more comprehensive understanding of
's role in AD, we performed RNA-sequencing on an AD-...
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Full title
The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_8794427b24664e6d86a8a5394eb6994b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8794427b24664e6d86a8a5394eb6994b
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ISSN
1662-4548,1662-453X
E-ISSN
1662-453X
DOI
10.3389/fnins.2017.00702
