The sheddase ADAM10 is a potent modulator of prion disease
The sheddase ADAM10 is a potent modulator of prion disease
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative proteinopathies such as Alzheimer's disease. PrP(C) is shed at the plasma membrane by the metallop...
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The sheddase ADAM10 is a potent modulator of prion disease
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TN_cdi_doaj_primary_oai_doaj_org_article_87cbc91b5c0144a38b87e7e8a5b595d5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_87cbc91b5c0144a38b87e7e8a5b595d5
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.04260
