Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinso...
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease
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Author / Creator
Marrone, Lara , Bus, Christine , Schöndorf, David , Fitzgerald, Julia Catherine , Kübler, Manuela , Schmid, Benjamin , Reinhardt, Peter , Reinhardt, Lydia , Deleidi, Michela , Levin, Tanya , Meixner, Andrea , Klink, Barbara , Glatza, Michael , Gloeckner, Christian Johannes , Gasser, Thomas and Sterneckert, Jared
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Induced pluripotent stem cells (iPSCs) have recapitulated several aspects of Parkinson's disease (PD), but most iPSCs are derived from familial cases, which account for only about 15% of patients. Thus, while the emphasis has justifiably been on using iPSCs to model rare familial cases, models for the most common forms of PD are critically lacking....
Alternative Titles
Full title
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_880fb56cc2ff42b4bad956b902f0d7d5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_880fb56cc2ff42b4bad956b902f0d7d5
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0192497
