TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signal...
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway
About this item
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Author / Creator
Lv, Zhongyang , Xu, Xingquan , Sun, Ziying , Yang, Yannick Xiaofan , Guo, Hu , Li, Jiawei , Sun, Kuoyang , Wu, Rui , Xu, Jia , Jiang, Qing , Ikegawa, Shiro and Shi, Dongquan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates the pathological process. However, precise therapies for M1 macrophage to decrease synovitis and attenuate OA progression have been scarcely proposed. Transient receptor potential vanilloid 1 (TRPV1) is a cation channel that has been...
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Full title
TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8910bc3fbc134babb723f638f6286252
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8910bc3fbc134babb723f638f6286252
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03792-8
