Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
About this item
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Author / Creator
Wang, Xiaolong , Liu, Jing , Niu, Yiyuan , Li, Yan , Zhou, Shiwei , Li, Chao , Ma, Baohua , Kou, Qifang , Petersen, Bjoern , Sonstegard, Tad , Huang, Xingxu , Jiang, Yu and Chen, Yulin
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
The simplicity of the CRISPR/Cas9 system has enabled its widespread applications in generating animal models, functional genomic screening and in treating genetic and infectious diseases. However, unintended mutations produced by off-target CRISPR/Cas9 nuclease activity may lead to negative consequences. Especially, a very recent study found that g...
Alternative Titles
Full title
Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8acf8044cee840d4814a0d901652a6df
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8acf8044cee840d4814a0d901652a6df
Other Identifiers
ISSN
1471-2164
E-ISSN
1471-2164
DOI
10.1186/s12864-018-4712-z
