Regulation of local GTP availability controls RAC1 activity and cell invasion
Regulation of local GTP availability controls RAC1 activity and cell invasion
About this item
Full title
Author / Creator
Bianchi-Smiraglia, Anna , Wolff, David W. , Marston, Daniel J. , Deng, Zhiyong , Han, Zhannan , Moparthy, Sudha , Wombacher, Rebecca M. , Mussell, Ashley L. , Shen, Shichen , Chen, Jialin , Yun, Dong-Hyun , O’Brien Cox, Anderson , Furdui, Cristina M. , Hurley, Edward , Feltri, Maria Laura , Qu, Jun , Hollis, Thomas , Kengne, Jules Berlin Nde , Fongang, Bernard , Sousa, Rui J. , Kandel, Mikhail E. , Kandel, Eugene S. , Hahn, Klaus M. and Nikiforov, Mikhail A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than the in vitro RAC1 GTP dissociation constant (RAC1-GTP Kd). Here, by combining genetically encoded GTP...
Alternative Titles
Full title
Regulation of local GTP availability controls RAC1 activity and cell invasion
Authors, Artists and Contributors
Author / Creator
Wolff, David W.
Marston, Daniel J.
Deng, Zhiyong
Han, Zhannan
Moparthy, Sudha
Wombacher, Rebecca M.
Mussell, Ashley L.
Shen, Shichen
Chen, Jialin
Yun, Dong-Hyun
O’Brien Cox, Anderson
Furdui, Cristina M.
Hurley, Edward
Feltri, Maria Laura
Qu, Jun
Hollis, Thomas
Kengne, Jules Berlin Nde
Fongang, Bernard
Sousa, Rui J.
Kandel, Mikhail E.
Kandel, Eugene S.
Hahn, Klaus M.
Nikiforov, Mikhail A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8aee079d643942f4a47c971818bffc85
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8aee079d643942f4a47c971818bffc85
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26324-6
