High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenu...
High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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While suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation of methylated DNA, reactivating gene expression. We here report generation of a high-fidelity CRISPR/Cas...
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High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis
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TN_cdi_doaj_primary_oai_doaj_org_article_8afce270d13543dc99f4fba3b97f9f22
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8afce270d13543dc99f4fba3b97f9f22
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05766-5
