Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
About this item
Full title
Author / Creator
Houshmand, Mohammad , Vitale, Nicoletta , Orso, Francesca , Cignetti, Alessandro , Molineris, Ivan , Gaidano, Valentina , Sainas, Stefano , Giorgis, Marta , Boschi, Donatella , Fava, Carmen , Passoni, Alice , Gai, Marta , Geuna, Massimo , Sora, Federica , Iurlo, Alessandra , Abruzzese, Elisabetta , Breccia, Massimo , Mulas, Olga , Caocci, Giovanni , Castagnetti, Fausto , Taverna, Daniela , Oliviero, Salvatore , Pane, Fabrizio , Lolli, Marco Lucio , Circosta, Paola and Saglio, Giuseppe
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has led to the high overall survival of chronic myeloid leukemia (CML) patients. However, there are CML patients who show resistance to TKI therapy and are prone to progress to more advanced phases of the disease. So, implementing an alternative approach for targ...
Alternative Titles
Full title
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
Authors, Artists and Contributors
Author / Creator
Vitale, Nicoletta
Orso, Francesca
Cignetti, Alessandro
Molineris, Ivan
Gaidano, Valentina
Sainas, Stefano
Giorgis, Marta
Boschi, Donatella
Fava, Carmen
Passoni, Alice
Gai, Marta
Geuna, Massimo
Sora, Federica
Iurlo, Alessandra
Abruzzese, Elisabetta
Breccia, Massimo
Mulas, Olga
Caocci, Giovanni
Castagnetti, Fausto
Taverna, Daniela
Oliviero, Salvatore
Pane, Fabrizio
Lolli, Marco Lucio
Circosta, Paola
Saglio, Giuseppe
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8b9664dc6202406c8f68c1be24352acf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8b9664dc6202406c8f68c1be24352acf
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05028-9
