Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting the SH2 domains have long been stymied by the poor drug-like properties of phosphate and its mimetics. Here, we use structure-based design to target the SH2 domain of...
Alternative Titles
Full title
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8bf42e914ed440c3a94fb07330693da9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8bf42e914ed440c3a94fb07330693da9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41894-3
