Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Structure-based drug design has often been restricted by the rather static picture of protein–ligand complexes presented by crystal structures, despite the widely accepted importance of protein flexibility in biomolecular recognition. Here we report a detailed experimental and computational study of the drug target, human heat shock protein 90, to...
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Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
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TN_cdi_doaj_primary_oai_doaj_org_article_8cad50c6a80c4f728aa29dd8ed5e414e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8cad50c6a80c4f728aa29dd8ed5e414e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02258-w
