Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (M
pro
), critical for viral replication, is a key target for therapeutic development. An organoselenium drug called ebselen has been demonstrated to have potent M
pro
inhibition and antiviral activity. We have examined the bind...
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Full title
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
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TN_cdi_doaj_primary_oai_doaj_org_article_8cf917f0f0d94c58998c45d6d9518f5b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8cf917f0f0d94c58998c45d6d9518f5b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23313-7
