Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 del...
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice
About this item
Full title
Author / Creator
Maresch, Roman , Mueller, Sebastian , Veltkamp, Christian , Öllinger, Rupert , Friedrich, Mathias , Heid, Irina , Steiger, Katja , Weber, Julia , Engleitner, Thomas , Barenboim, Maxim , Klein, Sabine , Louzada, Sandra , Banerjee, Ruby , Strong, Alexander , Stauber, Teresa , Gross, Nina , Geumann, Ulf , Lange, Sebastian , Ringelhan, Marc , Varela, Ignacio , Unger, Kristian , Yang, Fengtang , Schmid, Roland M. , Vassiliou, George S. , Braren, Rickmer , Schneider, Günter , Heikenwalder, Mathias , Bradley, Allan , Saur, Dieter and Rad, Roland
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas of adult mice, allowing simultaneous editing of multiple gene sets in individual cells. We use the method to induce pancreati...
Alternative Titles
Full title
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice
Authors, Artists and Contributors
Author / Creator
Mueller, Sebastian
Veltkamp, Christian
Öllinger, Rupert
Friedrich, Mathias
Heid, Irina
Steiger, Katja
Weber, Julia
Engleitner, Thomas
Barenboim, Maxim
Klein, Sabine
Louzada, Sandra
Banerjee, Ruby
Strong, Alexander
Stauber, Teresa
Gross, Nina
Geumann, Ulf
Lange, Sebastian
Ringelhan, Marc
Varela, Ignacio
Unger, Kristian
Yang, Fengtang
Schmid, Roland M.
Vassiliou, George S.
Braren, Rickmer
Schneider, Günter
Heikenwalder, Mathias
Bradley, Allan
Saur, Dieter
Rad, Roland
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8d54419326794a6ba55ff4332e373a04
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d54419326794a6ba55ff4332e373a04
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10770
