Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
About this item
Full title
Author / Creator
Publisher
London: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
London: BioMed Central
Subjects
More information
Scope and Contents
Contents
Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity. Our collection of 53 drug-response predictors attains an average bal...
Alternative Titles
Full title
Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8d63f66e5204442188fe04baf4456244
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8d63f66e5204442188fe04baf4456244
Other Identifiers
ISSN
1756-994X
E-ISSN
1756-994X
DOI
10.1186/s13073-020-00774-x
