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ArticlesPeer ReviewedFull Text
NTRK fusion-positive cancers and TRK inhibitor therapy
Author / Creator:Cocco, Emiliano ; Scaltriti, Maurizio ; Drilon, Alexander
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Clinical oncology, 2018-12, Vol.15 (12), p.731-747
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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
Author / Creator:Toska, Eneda ; Osmanbeyoglu, Hatice U. ; Castel, Pau ; Chan, Carmen ; Hendrickson, Ronald C. ; Elkabets, Moshe ; Dickler, Maura N. ; Scaltriti, Maurizio ; Leslie, Christina S. ; Armstrong, Scott A. ; Baselga, José
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6331), p.1324-1330
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Resistance to TRK inhibition mediated by convergent MAPK pathway activation
Author / Creator:Cocco, Emiliano ; Schram, Alison M. ; Kulick, Amanda ; Misale, Sandra ; Won, Helen H. ; Yaeger, Rona ; Razavi, Pedram ; Ptashkin, Ryan ; Hechtman, Jaclyn F. ; Toska, Eneda ; Cownie, James ; Somwar, Romel ; Shifman, Sophie ; Mattar, Marissa ; Selçuklu, S. Duygu ; Samoila, Aliaksandra ; Guzman, Sean ; Tuch, Brian B. ; Ebata, Kevin ; de Stanchina, Elisa ; Nagy, Rebecca J. ; Lanman, Richard B. ; Houck-Loomis, Brian ; Patel, Juber A. ; Berger, Michael F. ; Ladanyi, Marc ; Hyman, David M. ; Drilon, Alexander ; Scaltriti, Maurizio
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-09, Vol.25 (9), p.1422-1427
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ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer
Author / Creator:Xu, Guotai ; Chhangawala, Sagar ; Cocco, Emiliano ; Razavi, Pedram ; Cai, Yanyan ; Otto, Jordan E ; Ferrando, Lorenzo ; Selenica, Pier ; Ladewig, Erik ; Chan, Carmen ; Da Cruz Paula, Arnaud ; Witkin, Matthew ; Cheng, Yuanming ; Park, Jane ; Serna-Tamayo, Cristian ; Zhao, HuiYong ; Wu, Fan ; Sallaku, Mirna ; Qu, Xuan ; Zhao, Alison ; Collings, Clayton K ; D’Avino, Andrew R. ; Jhaveri, Komal ; Koche, Richard ; Levine, Ross L. ; Reis-Filho, Jorge S. ; Kadoch, Cigall ; Scaltriti, Maurizio ; Leslie, Christina S. ; Baselga, José ; Toska, Eneda
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2020-02, Vol.52 (2), p.198-207
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Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study
Author / Creator:Alborelli, Ilaria ; Generali, Daniele ; Jermann, Philip ; Cappelletti, Maria Rosa ; Ferrero, Giuseppina ; Scaggiante, Bruna ; Bortul, Marina ; Zanconati, Fabrizio ; Nicolet, Stefan ; Haegele, Jasmin ; Bubendorf, Lukas ; Aceto, Nicola ; Scaltriti, Maurizio ; Mucci, Giuseppe ; Quagliata, Luca ; Novelli, Giuseppe
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2019-07, Vol.10 (7), p.534-11, Article 534
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UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth
Author / Creator:Wolfe, Andrew L. ; Zhou, Qingwen ; Toska, Eneda ; Galeas, Jacqueline ; Ku, Angel A. ; Koche, Richard P. ; Bandyopadhyay, Sourav ; Scaltriti, Maurizio ; Lebrilla, Carlito B. ; McCormick, Frank ; Kim, Sung Eun
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (31), p.1-7
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Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma
Author / Creator:Mizrachi, Aviram ; Shamay, Yosi ; Shah, Janki ; Brook, Samuel ; Soong, Joanne ; Rajasekhar, Vinagolu K. ; Humm, John L. ; Healey, John H. ; Powell, Simon N. ; Baselga, José ; Heller, Daniel A. ; Haimovitz-Friedman, Adriana ; Scaltriti, Maurizio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-02, Vol.8 (1), p.14292-14292, Article 14292
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Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
Author / Creator:Cook, Peter J. ; Thomas, Rozario ; Kannan, Ram ; de Leon, Esther Sanchez ; Drilon, Alexander ; Rosenblum, Marc K. ; Scaltriti, Maurizio ; Benezra, Robert ; Ventura, Andrea
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-07, Vol.8 (1), p.15987-15987, Article 15987
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Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients
Author / Creator:Scaltriti, Maurizio ; Eichhorn, Pieter J ; Cortés, Javier ; Prudkin, Ludmila ; Aura, Claudia ; Jiménez, José ; Chandarlapaty, Sarat ; Serra, Violeta ; Prat, Aleix ; Ibrahim, Yasir H ; Guzmán, Marta ; Gili, Magui ; Rodríguez, Olga ; Rodríguez, Sonia ; Pérez, José ; Green, Simon R ; Mai, Sabine ; Rosen, Neal ; Hudis, Clifford ; Baselga, José
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (9), p.3761-3766
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Shifting the paradigm in personalized cancer care through next‐generation therapeutics and computational pathology
Author / Creator:Reis‐Filho, Jorge S. ; Scaltriti, Maurizio ; Kapil, Ansh ; Sade, Hadassah ; Galbraith, Susan
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2024-11, Vol.18 (11), p.2607-2611
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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas
Author / Creator:Ebbesen, Saya H. ; Scaltriti, Maurizio ; Bialucha, Carl U. ; Morse, Natasha ; Kastenhuber, Edward R. ; Wen, Hannah Y. ; Dow, Lukas E. ; Baselga, José ; Lowe, Scott W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (11), p.3030-3035
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Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
Author / Creator:Floros, Konstantinos V. ; Jacob, Sheeba ; Kurupi, Richard ; Fairchild, Carter K. ; Hu, Bin ; Puchalapalli, Madhavi ; E. Koblinski, Jennifer ; Dozmorov, Mikhail G. ; Boikos, Sosipatros A. ; Scaltriti, Maurizio ; Faber, Anthony C.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2021-02, Vol.12 (2), p.179-13, Article 179
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Phase and context shape the function of composite oncogenic mutations
Author / Creator:Gorelick, Alexander N. ; Sánchez-Rivera, Francisco J. ; Cai, Yanyan ; Bielski, Craig M. ; Biederstedt, Evan ; Jonsson, Philip ; Richards, Allison L. ; Vasan, Neil ; Penson, Alexander V. ; Friedman, Noah D. ; Ho, Yu-Jui ; Baslan, Timour ; Bandlamudi, Chaitanya ; Scaltriti, Maurizio ; Schultz, Nikolaus ; Lowe, Scott W. ; Reznik, Ed ; Taylor, Barry S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-06, Vol.582 (7810), p.100-103
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RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer
Author / Creator:Serra, Violeta ; Eichhorn, Pieter J.A. ; García-García, Celina ; Ibrahim, Yasir H. ; Prudkin, Ludmila ; Sánchez, Gertrudis ; Rodríguez, Olga ; Antón, Pilar ; Parra, Josep-Lluís ; Marlow, Sara ; Scaltriti, Maurizio ; Pérez-Garcia, José ; Prat, Aleix ; Arribas, Joaquín ; Hahn, William C. ; Kim, So Young ; Baselga, José
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-06, Vol.123 (6), p.2551-2563
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Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas
Author / Creator:Benhamida, Jamal K. ; Vyas, Monika ; Tanaka, Atsushi ; Wang, Lu ; Bahrami, Armita ; Ozcan, Kerem ; Basturk, Olca ; Villafania, Liliana ; Mata, Douglas A. ; El Jabbour, Tony ; Selenica, Pier ; Roehrl, M.H.A. ; Weigelt, Britta ; Reis-Filho, Jorge S. ; Scaltriti, Maurizio ; Klimstra, David S.
Publisher:New York: Elsevier Inc
Journal title:Modern pathology, 2022-07, Vol.35 (7), p.956-961
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Targeted drug delivery strategies for precision medicines
Author / Creator:Manzari, Mandana T. ; Shamay, Yosi ; Kiguchi, Hiroto ; Rosen, Neal ; Scaltriti, Maurizio ; Heller, Daniel A.
Journal title:Nature reviews. Materials, 2021-04, Vol.6 (4), p.351-370
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Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway
Author / Creator:Selenica, Pier ; Raj, Nitya ; Kumar, Rahul ; Brown, David N. ; Arqués, Oriol ; Reidy, Diane ; Klimstra, David ; Snuderl, Matija ; Serrano, Jonathan ; Palmer, Héctor G. ; Weigelt, Britta ; Reis‐Filho, Jorge S. ; Scaltriti, Maurizio
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2019-08, Vol.13 (8), p.1684-1692
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Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns
Author / Creator:Mateo, Lidia ; Duran-Frigola, Miquel ; Gris-Oliver, Albert ; Palafox, Marta ; Scaltriti, Maurizio ; Razavi, Pedram ; Chandarlapaty, Sarat ; Arribas, Joaquin ; Bellet, Meritxell ; Serra, Violeta ; Aloy, Patrick
Publisher:London: BioMed Central
Journal title:Genome medicine, 2020-09, Vol.12 (1), p.1-78, Article 78
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Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation
Author / Creator:Anido, Judit ; Scaltriti, Maurizio ; Bech Serra, Joan Josep ; Josefat, Belén Santiago ; Rojo Todo, Federico ; Baselga, José ; Arribas, Joaquín
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2006-07, Vol.25 (13), p.3234-3244
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ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins
Author / Creator:Alcon, Clara ; Gómez Tejeda Zañudo, Jorge Gómez Tejeda ; Albert, Reka ; Wagle, Nikhil ; Scaltriti, Maurizio ; Letai, Anthony ; Samitier, Josep ; Montero, Joan
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-07, Vol.10 (7), p.1659
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Showing 1 to 20 of 66 results

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NTRK fusion-positive cancers and TRK inhibitor therapy

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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

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Resistance to TRK inhibition mediated by convergent MAPK pathway activation

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ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

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Cell-free DNA analysis in healthy individuals by next-generation sequencing: a proof of concept and technical validation study

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UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

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Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

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Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

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Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients

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Shifting the paradigm in personalized cancer care through next‐generation therapeutics and computational pathology

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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

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Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors

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Phase and context shape the function of composite oncogenic mutations

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RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer

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Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas

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Targeted drug delivery strategies for precision medicines

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Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway

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Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

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Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation

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ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins

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