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The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and i...

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and i...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8db15ecafd10424f871166f1a680e322

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

About this item

Full title

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

Publisher

England: The Company of Biologists Ltd

Journal title

Disease models & mechanisms, 2018-01, Vol.11 (1)

Language

English

Formats

Publication information

Publisher

England: The Company of Biologists Ltd

More information

Scope and Contents

Contents

Members of the Junctophilin (JPH) protein family have emerged as key actors in all excitable cells, with crucial implications for human pathophysiology. In mammals, this family consists of four members (JPH1-JPH4) that are differentially expressed throughout excitable cells. The analysis of knockout mice lacking JPH subtypes has demonstrated their...

Alternative Titles

Full title

The Drosophila junctophilin gene is functionally equivalent to its four mammalian counterparts and is a modifier of a Huntingtin poly-Q expansion and the Notch pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_8db15ecafd10424f871166f1a680e322

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8db15ecafd10424f871166f1a680e322

Other Identifiers

ISSN

1754-8403,1754-8411

E-ISSN

1754-8411

DOI

10.1242/dmm.029082

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