Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by s...
Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Gene vectors to treat cystic fibrosis lung disease should be targeted to the conducting airways, as peripheral lung transduction does not offer therapeutic benefit. Viral transduction efficiency is directly related to the vector residence time. However, delivered fluids such as gene vectors naturally spread to the alveoli during inspiration, and th...
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Full title
Improved in-vivo airway gene transfer via magnetic-guidance, with protocol development informed by synchrotron imaging
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TN_cdi_doaj_primary_oai_doaj_org_article_8e5066133a14494fa29a90749fcb2c7c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8e5066133a14494fa29a90749fcb2c7c
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-12895-x
