CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
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Author / Creator
Bartuzi, Paulina , Billadeau, Daniel D. , Favier, Robert , Rong, Shunxing , Dekker, Daphne , Fedoseienko, Alina , Fieten, Hille , Wijers, Melinde , Levels, Johannes H. , Huijkman, Nicolette , Kloosterhuis, Niels , van der Molen, Henk , Brufau, Gemma , Groen, Albert K. , Elliott, Alison M. , Kuivenhoven, Jan Albert , Plecko, Barbara , Grangl, Gernot , McGaughran, Julie , Horton, Jay D. , Burstein, Ezra , Hofker, Marten H. and van de Sluis, Bart
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott–Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal sorting of LDLR and for its function. We find that...
Alternative Titles
Full title
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Authors, Artists and Contributors
Author / Creator
Billadeau, Daniel D.
Favier, Robert
Rong, Shunxing
Dekker, Daphne
Fedoseienko, Alina
Fieten, Hille
Wijers, Melinde
Levels, Johannes H.
Huijkman, Nicolette
Kloosterhuis, Niels
van der Molen, Henk
Brufau, Gemma
Groen, Albert K.
Elliott, Alison M.
Kuivenhoven, Jan Albert
Plecko, Barbara
Grangl, Gernot
McGaughran, Julie
Horton, Jay D.
Burstein, Ezra
Hofker, Marten H.
van de Sluis, Bart
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8e60ef48969c43c189785a273159992f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8e60ef48969c43c189785a273159992f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10961
