SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma
SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma
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Author / Creator
Tan, Kezhe , Mo, Jialin , Li, Meng , Dong, Yu , Han, Yujie , Sun, Xi , Ma, Yingxuan , Zhu, Kai , Wu, Wei , Lu, Li , Liu, Jiangbin , Zhao, Kewen , Zhang, Lei , Tang, Yujie and Lv, Zhibao
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Neuroblastoma (NB) is the most common extracranial solid tumor occurring during childhood and high-risk NB patients have a poor prognosis. The amplified MYCN gene serves as an important determinant of a high risk of NB.
We performed an integrative screen using public NB tissue and cell line data, and identified that SMAD9 played an important rol...
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Full title
SMAD9-MYCN positive feedback loop represents a unique dependency for MYCN-amplified neuroblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_8ee7d1777fec4e1fb387432e02826486
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8ee7d1777fec4e1fb387432e02826486
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-022-02563-3
