The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disea...
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease
About this item
Full title
Author / Creator
de Leon, Mony J , Pirraglia, Elizabeth , Osorio, Ricardo S , Glodzik, Lidia , Saint-Louis, Les , Kim, Hee-Jin , Fortea, Juan , Fossati, Silvia , Laska, Eugene , Siegel, Carole , Butler, Tracy , Li, Yi , Rusinek, Henry , Zetterberg, Henrik , Blennow, Kaj , National Alzheimer’s Coordinating Center , Alzheimer’s Disease Neuroimaging Initiative , the Alzheimer’s Disease Neuroimaging Initiative and the National Alzheimer’s Coordinating Center
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Cerebrospinal fluid (CSF) studies consistently show that CSF levels of amyloid-beta 1-42 (Aβ42) are reduced and tau levels increased prior to the onset of cognitive decline related to Alzheimer's disease (AD). However, the preclinical prediction accuracy for low CSF Aβ42 levels, a surrogate for brain Aβ42 deposits, is not high. Moreover, the pathol...
Alternative Titles
Full title
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease
Authors, Artists and Contributors
Author / Creator
Pirraglia, Elizabeth
Osorio, Ricardo S
Glodzik, Lidia
Saint-Louis, Les
Kim, Hee-Jin
Fortea, Juan
Fossati, Silvia
Laska, Eugene
Siegel, Carole
Butler, Tracy
Li, Yi
Rusinek, Henry
Zetterberg, Henrik
Blennow, Kaj
National Alzheimer’s Coordinating Center
Alzheimer’s Disease Neuroimaging Initiative
the Alzheimer’s Disease Neuroimaging Initiative
the National Alzheimer’s Coordinating Center
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_8f47b6c9c8dc48a7bf8202251285bd2e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_8f47b6c9c8dc48a7bf8202251285bd2e
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0191240
