Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2...
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Selenoprotein P (SeP) functions as a selenium (Se)-supply protein. SeP is identified as a hepatokine, promoting insulin resistance in type 2 diabetes. Thus, the suppression of Se-supply activity of SeP might improve glucose metabolism. Here, we develop an anti-human SeP monoclonal antibody AE2 as with neutralizing activity against SeP. Administrati...
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Full title
Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
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TN_cdi_doaj_primary_oai_doaj_org_article_9072caa59698443ba30fe40fdc34e5b3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9072caa59698443ba30fe40fdc34e5b3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01863-z
