The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The complex kinetics of disease-related amyloid aggregation of proteins such as α-Synuclein (α-Syn) in Parkinson’s disease and Aβ42 in Alzheimer’s disease include primary nucleation, amyloid fibril elongation and secondary nucleation. The latter can be a key accelerator of the aggregation process. It has been demonstrated that the chaperone domain...
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The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_90c928bc7c7542db836b296434e76fdf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_90c928bc7c7542db836b296434e76fdf
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54212-2
