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Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

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Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_90de263ab4864245afd1b4be5c061876

Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

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England: BioMed Central Ltd

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One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing of the same epitopes on normal tissues. To elevate the safety profile of CAR-T cells, an affinity/avidity fine-tuned CAR was designed enabling CAR-T cell activation onl...

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Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

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TN_cdi_doaj_primary_oai_doaj_org_article_90de263ab4864245afd1b4be5c061876

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_90de263ab4864245afd1b4be5c061876

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ISSN

1476-4598

E-ISSN

1476-4598

DOI

10.1186/s12943-024-01952-w

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