Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2
Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2
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Switzerland: Frontiers Research Foundation
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Language
English
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Switzerland: Frontiers Research Foundation
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In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl(-))-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl(-) concentration ([Cl(-)]i). Lowering [Cl(-)]i enhances inhibition, whereas raising [Cl(-)]i facilitates neuronal activity. A neuron's basal level of [Cl(-)]i, as well as...
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Full title
Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2
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TN_cdi_doaj_primary_oai_doaj_org_article_911001f5b76c497fa9b5c156a8eb014d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_911001f5b76c497fa9b5c156a8eb014d
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ISSN
1662-5102
E-ISSN
1662-5102
DOI
10.3389/fncel.2014.00027
