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Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in c...

Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in c...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_918343b440734d17bc412c64bc7f7a9f

Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes

About this item

Full title

Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes

Publisher

United States: John Wiley & Sons, Inc

Journal title

Hepatology Communications, 2022-10, Vol.6 (10), p.2748-2764

Language

English

Formats

Publication information

Publisher

United States: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

Fluid and bicarbonate secretion is a principal function of cholangiocytes, and impaired secretion results in cholestasis. Cholangiocyte secretion depends on peri‐apical expression of the type 3 inositol trisphosphate receptor (ITPR3), and loss of this intracellular Ca2+ release channel is a final common event in most cholangiopathies. Here we inves...

Alternative Titles

Full title

Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_918343b440734d17bc412c64bc7f7a9f

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_918343b440734d17bc412c64bc7f7a9f

Other Identifiers

ISSN

2471-254X

E-ISSN

2471-254X

DOI

10.1002/hep4.2042

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