mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function...
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
About this item
Full title
Author / Creator
Obraztsova, Kseniya , Basil, Maria C. , Rue, Ryan , Sivakumar, Aravind , Lin, Susan M. , Mukhitov, Alexander R. , Gritsiuta, Andrei I. , Evans, Jilly F. , Kopp, Meghan , Katzen, Jeremy , Robichaud, Annette , Atochina-Vasserman, Elena N. , Li, Shanru , Carl, Justine , Babu, Apoorva , Morley, Michael P. , Cantu, Edward , Beers, Michael F. , Frank, David B. , Morrisey, Edward E. and Krymskaya, Vera P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in
tuberous sclerosis complex (TSC1/TSC2)
genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin of LAM cells is still unknown. Here, we profile a LAM lung compared to an age- and sex-matched...
Alternative Titles
Full title
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
Authors, Artists and Contributors
Author / Creator
Basil, Maria C.
Rue, Ryan
Sivakumar, Aravind
Lin, Susan M.
Mukhitov, Alexander R.
Gritsiuta, Andrei I.
Evans, Jilly F.
Kopp, Meghan
Katzen, Jeremy
Robichaud, Annette
Atochina-Vasserman, Elena N.
Li, Shanru
Carl, Justine
Babu, Apoorva
Morley, Michael P.
Cantu, Edward
Beers, Michael F.
Frank, David B.
Morrisey, Edward E.
Krymskaya, Vera P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_920f2bde4ce048d5a6bf73943fc2fe6e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_920f2bde4ce048d5a6bf73943fc2fe6e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18979-4
