The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
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Author / Creator
Abed, Mona , Verschueren, Erik , Budayeva, Hanna , Liu, Peter , Kirkpatrick, Donald S , Reja, Rohit , Kummerfeld, Sarah K , Webster, Joshua D , Gierke, Sarah , Reichelt, Mike , Anderson, Keith R , Newman, Robert J , Roose-Girma, Merone , Modrusan, Zora , Pektas, Hazal , Maltepe, Emin , Newton, Kim and Dixit, Vishva M
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long terminal repeat) retrotransposon and retains Gag and Pol-like domains. Here we show that the Gag domain of PEG10 can promote vesicle budding similar to the HIV p24 Gag protein. Expressed in a subs...
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Full title
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification
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TN_cdi_doaj_primary_oai_doaj_org_article_93959bf6c69541c08084758f11b3be34
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_93959bf6c69541c08084758f11b3be34
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0214110
