Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
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Author / Creator
Knittel, Gero , Rehkämper, Tim , Korovkina, Darya , Liedgens, Paul , Fritz, Christian , Torgovnick, Alessandro , Al-Baldawi, Yussor , Al-Maarri, Mona , Cun, Yupeng , Fedorchenko, Oleg , Riabinska, Arina , Beleggia, Filippo , Nguyen, Phuong-Hien , Wunderlich, F. Thomas , Ortmann, Monika , Montesinos-Rongen, Manuel , Tausch, Eugen , Stilgenbauer, Stephan , P. Frenzel, Lukas , Herling, Marco , Herling, Carmen , Bahlo, Jasmin , Hallek, Michael , Peifer, Martin , Buettner, Reinhard , Persigehl, Thorsten and Reinhardt, H. Christian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Chronic lymphocytic leukemia (CLL) remains an incurable disease. Two recurrent cytogenetic aberrations, namely del(17p), affecting
TP53
, and del(11q), affecting
ATM
, are associated with resistance against genotoxic chemotherapy (del17p) and poor outcome (del11q and del17p). Both del(17p) and del(11q) are also associated with inferior...
Alternative Titles
Full title
Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
Authors, Artists and Contributors
Author / Creator
Rehkämper, Tim
Korovkina, Darya
Liedgens, Paul
Fritz, Christian
Torgovnick, Alessandro
Al-Baldawi, Yussor
Al-Maarri, Mona
Cun, Yupeng
Fedorchenko, Oleg
Riabinska, Arina
Beleggia, Filippo
Nguyen, Phuong-Hien
Wunderlich, F. Thomas
Ortmann, Monika
Montesinos-Rongen, Manuel
Tausch, Eugen
Stilgenbauer, Stephan
P. Frenzel, Lukas
Herling, Marco
Herling, Carmen
Bahlo, Jasmin
Hallek, Michael
Peifer, Martin
Buettner, Reinhard
Persigehl, Thorsten
Reinhardt, H. Christian
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_93c8b6674f2b4c01a38589c9951b35af
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_93c8b6674f2b4c01a38589c9951b35af
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00210-6
