Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes...
Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear. One of the main hypotheses known as the snail-tong mechanism assumes that in the inactive state, the death do...
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Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis
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TN_cdi_doaj_primary_oai_doaj_org_article_93e81a0ed52f4a949f2c31ba9f7ec4c9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_93e81a0ed52f4a949f2c31ba9f7ec4c9
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2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-70721-8
