TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas u...
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT
About this item
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Author / Creator
de Nonneville, Alexandre , Salas, Sébastien , Bertucci, François , Sobinoff, Alexander P , Adélaïde, José , Guille, Arnaud , Finetti, Pascal , Noble, Jane R , Churikov, Dimitri , Chaffanet, Max , Lavit, Elise , Pickett, Hilda A , Bouvier, Corinne , Birnbaum, Daniel , Reddel, Roger R and Géli, Vincent
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (
ATRX
) gene is mutated leading to the conclusion that the ATRX complex represses ALT. Here, we report that most high‐grade pediatric osteosarcomas mai...
Alternative Titles
Full title
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_948680b27447452fa822018d83b4b8e5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_948680b27447452fa822018d83b4b8e5
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202215859
