Delicate balance among thermal stability, binding affinity, and conformational space explored by sin...
Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain V
H
H antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they are single-domain proteins. In this work, based on physicochemical measurements and molecu...
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Full title
Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies
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TN_cdi_doaj_primary_oai_doaj_org_article_94c6e8e43a92458194b1a6a09e1f51ed
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_94c6e8e43a92458194b1a6a09e1f51ed
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-98977-8
