Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
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Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Scope and Contents
Contents
The calcium release-activated calcium channel Orai regulates Ca
entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca
release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively open. Previously, using one such mutation (H206A), we o...
Alternative Titles
Full title
Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_95d2107fa1774fe6bb3ba54fe465fdff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_95d2107fa1774fe6bb3ba54fe465fdff
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.62772
