Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positi...
Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer
About this item
Full title
Author / Creator
Smyth, Lillian M. , Batist, Gerald , Meric-Bernstam, Funda , Kabos, Peter , Spanggaard, Iben , Lluch, Ana , Jhaveri, Komal , Varga, Andrea , Wong, Andrea , Schram, Alison M. , Ambrose, Helen , Carr, T. Hedley , de Bruin, Elza C. , Salinas-Souza, Carolina , Foxley, Andrew , Hauser, Joana , Lindemann, Justin P. O. , Maudsley, Rhiannon , McEwen, Robert , Moschetta, Michele , Nikolaou, Myria , Schiavon, Gaia , Razavi, Pedram , Banerji, Udai , Baselga, José , Hyman, David M. and Chandarlapaty, Sarat
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Five to ten percent of ER+ metastatic breast cancer (MBC) tumors harbor somatic
PTEN
mutations. Loss of function of this tumor-suppressor gene defines a highly aggressive, treatment-refractory disease for which new therapies are urgently needed. This Phase I multipart expansion study assessed oral capivasertib with fulvestrant in patients wit...
Alternative Titles
Full title
Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer
Authors, Artists and Contributors
Author / Creator
Batist, Gerald
Meric-Bernstam, Funda
Kabos, Peter
Spanggaard, Iben
Lluch, Ana
Jhaveri, Komal
Varga, Andrea
Wong, Andrea
Schram, Alison M.
Ambrose, Helen
Carr, T. Hedley
de Bruin, Elza C.
Salinas-Souza, Carolina
Foxley, Andrew
Hauser, Joana
Lindemann, Justin P. O.
Maudsley, Rhiannon
McEwen, Robert
Moschetta, Michele
Nikolaou, Myria
Schiavon, Gaia
Razavi, Pedram
Banerji, Udai
Baselga, José
Hyman, David M.
Chandarlapaty, Sarat
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_97cb292e26054c75a968bad21fc37c9b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_97cb292e26054c75a968bad21fc37c9b
Other Identifiers
ISSN
2374-4677
E-ISSN
2374-4677
DOI
10.1038/s41523-021-00251-7
