Replication collisions induced by de-repressed S-phase transcription are connected with malignant tr...
Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Transcription replication collisions (TRCs) constitute a major intrinsic source of genome instability but conclusive evidence for a causal role of TRCs in tumor initiation is missing. We discover that lack of the H4K20-dimethyltransferase KMT5B (also known as SUV4-20H1) in muscle stem cells de-represses S-phase transcription by increasing H4K20me1...
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Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_982571b2a822471e9f636df997aab30d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_982571b2a822471e9f636df997aab30d
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34577-y
