Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis
Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no attempt to neutralize IGF2 has been reported. We therefore studied the possibility to hamper rhabdomyosarco...
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Full title
Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_98c06761c44e458a8f112936ff488f59
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_98c06761c44e458a8f112936ff488f59
Other Identifiers
ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-019-5339-4
