Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the presence of the non-hydrolyzable ATP analog, ADP-beryllium fluoride, we observe additional interacti...
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Full title
Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes
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TN_cdi_doaj_primary_oai_doaj_org_article_990cf61399f44bdea9c20e0939ed572f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_990cf61399f44bdea9c20e0939ed572f
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.22510
