Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Phy...
Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling
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Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since (
)-clomiphene ((
)-Clom) and its metabolites are eliminated primarily via Cytochrome P450 (CYP) 2D6 and CYP3A4, exposure can be affected by CYP2D6 polymorphisms and concomitant use with CYP inhibit...
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Full title
Prediction of Drug-Drug-Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling
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TN_cdi_doaj_primary_oai_doaj_org_article_9986fda8e97f4f16bc07634d0d38153f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_9986fda8e97f4f16bc07634d0d38153f
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ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics14122604
